Warfarin overdose

– Off Warfarin

– Vitamin K
5-10 mg + 5%DW/NSS at least 50 mL
IV drip over 20 min
ให้แบบนี้เพื่อลด risk ของ anaphylactoid rxn
[Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G. Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e44S-88S.]

15-20 mL/kg IV free flow
ให้เพื่อชดเชย Vitamin K-dependent factors: 2, 7, 9, 10

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